Prevention Institute’s recommendations to prevent gun violence begin with attention to reducing immediate risks related to guns, broaden to address the underlying contributors to gun violence, and then address the prevention infrastructure necessary to ensure effectiveness. We also include recommendations related to new frontiers for research and practice, to ensure that we continue to learn, innovate, and increase our impact over time. The set of recommendations illustrate that one program or policy alone is not going to significantly reduce gun violence, but rather, through comprehensive strategies, we can achieve safety in our homes, schools, and communities.